New trainee doctor Lily jumps straight in to investigate a disastrous robbery on the open road, while Dixie builds a bond with an old woman to help her carry out a romantic mission.
Nurse Rita is late for her first shift as she contends with an injured neighbour whose hoarding has got out of control, while Jamie bonds with a failed asylum seeker too scared to tell the authorities he's gay.
Jamie almost brings the whole ED to a standstill as he becomes further embroiled in trying to assist an Iranian immigrant, and Sam's maternal skills are revealed as she rescues the baby of a broken family.
Ash and Jeff are forced to dive into the sea to save a teenager who's been tombstoning, while Fletch and Rita treat a boy who is claiming to be the reincarnation of an elderly lady's brother.
Lily is assigned to an emotional case involving a teenage cancer patient in order to learn some empathy, while Charlie investigates an act of heroism as a bus crash unravels a web of deceit.
Treating two brothers who come to blows with a drug dealer tests Iain and Jeff's ability to get on, while Jamie susses out that a patient is faking it to get his mothers attention.
Rita and Ash look after a young girl who's keeping secrets from her charming boyfriend, and Fletch is worried about two sisters who are struggling to look after each other as they get older.
Iain helps a teenager caught up in a fatal car crash face up to the truth, while Fletch decides to shoulder the blame for Tess's mistake.
Tess has to confront her own problems when a pregnant woman is involved in an RTC and Robyn and Jamie witness the effects of a batch of bad pills on the Holby nightlife.
Ash and Tess work to discover why a mother and daughter are so at odds about how far the team should go to save the father's life while Jamie accidentally helps crack open a love triangle.
Rita's day with the paramedics brings her close to a patient in a serious entrapment, and Big Mac is able to make a real difference with a destitute man.
Jeff steps in to help a father and his sons who get into trouble over a hidden bag of cash, while Sam treats a bride on her wedding day, not knowing that Tom intends to propose.
Iain is deeply affected by two police officers who stir up his memories of army life, and Charlie tries to help a young family keep hold of their little girl.
Lily suspects steroids are to blame for a violent dispute between rugby players, while Sam and new porter Max help a policeman in pursuit of the truth.
The pressure is on Fletch who's trying to balance responsibility with helping a vulnerable boy, and Jamie unwittingly gives Lily a lesson in patient care.
Fletch rescues two teenage boys from a dangerous predator, Sam helps a former wartime spy regain her home, and Ash treats a girl who's accidentally eaten her cat's ashes.
Fletch has to rescue a child from danger when two brothers are involved in an accident, and Sam realises the truth about her own relationship when she re-starts the heart of a patient.
A young couple are forced to take refuge at a farm for the birth of their baby, and a man is electrocuted by a Christmas tree, disrupting Sam and Tom's wedding plans and causing Fletch to be arrested.
Fletch has a disastrous New Years Eve when there's an explosion in a bar, and Robyn helps a silent singer find his voice.
New doctor Ethan and Lily diagnose teacher Alice with a rare disease while Zoe and Tess fight to save the life of Dixie's girlfriend.
New Dr Cal goes to the rescue of a girl in a limo hanging precariously off a bridge while his brother Ethan uncovers the truth about an art student whose sight is endangered by flying glass.
Dixie's accused of assault after a man she and Rita think is a rapist trips and hits his head, while Ethan and Cal strive to help a little boy get his voice back.
Rita helps a rape victim gain the courage to press charges, while Zoe treats an eccentric ex-Tiller girl who must tell the truth about the daughter she put up for adoption.
On his last day at the ED, Jamie helps Cal and Ethan uncover abuse between a stepfather and his family, while Dixie and Jeff help extract a man from sinking river mud.
Iain defies orders and runs into a burning building to save a man in search of his new fiance, while Lily steps into the breach as a magician's assistant when pensioner Yvonne gets injured.
Fletch's daughter runs away from home and lands herself in danger, while Robyn has to discover why a teenage girl is lying.
Lily makes a special connection with a new mother with learning disabilities, while Robyn is intrigued by a mysterious intruder.
Iain tries to help a distressed ex-army friend and his wife, while Lofty's keen eye helps save a young man who must learn to stand up to his brother.
Big Mac and Iain are held hostage by an angry ex-soldier, while Charlie must learn the identity of a patient so the team can race to save her son.
Ethan's conscience is tested when an activist asks him to hide his secrets, while Rita and Zoe help a desperate prisoner repair his relationship with his mother.
New consultant Connie Beauchamp saves a man from prison on her first day at the ED, while Ash takes his wayward daughter in hand.
Connie, Zoe and Lily pull together to treat a father and his ADHD daughter, and Charlie helps an old biker come to terms with his wife's dementia.
Jeff, Rita and Lily help a morbidly obese man access the help he needs, and Dixie bonds with an angry young motorcyclist.
Fletch builds bridges between a father and son estranged by drugs, and Cal tries to impress Lily by discovering what's wrong with a man who thinks he's got a brain tumour.
Dixie risks her job to take a patient to see his dying mother, while another patient's unusual birthday treat to herself goes awry when she sniffs cocaine.
Dixie is given three months suspension by the Ambulance Trust and Connie makes Zoe question whether there was another procedure she could have tried in order to save a patient's life.
Ash realises the truth about his daughter when a patient's experience with drugs turns sour, while Fletch fights to repair a broken family on a couples wedding day.
Cal tries to help a family torn apart by sibling rivalry, while Tess tries to help a pregnant teenager stand up to her controlling father.
Connie tries to help a father come to terms with his son's sexuality, while Cal helps treat a severely paranoid patient.
Rita finds herself in a difficult situation when a fire breaks out in an elderly care home, while Lily helps a man with toothache realise the true extent of his problem.
The ED struggle with increasing numbers, Connie fights to save a man suffering from dementia, and Ethan and Rita work to convince a bulimic teenager that she needs help.
Zoe sticks up for the ED when the press turn up but a horrific helicopter accident is the last straw that pushes her to make a difficult decision.
Tess is involved in a horrendous crash and Fletch sacrifices everything to save her.
A cross-country obstacle race accident brings together a father and son as well as Jeff and his new love interest.
Connie helps an ill man tell his wife the truth, and a leukaemia survivor comes to realise that she isn't ready for a family yet.
Rita receives a visit from her past which may jeopardise her future, and Lofty and Cal bring a family back together with a bit of creative thinking.
Cal and Ethan work together to solve a medical mystery, while Rita helps a patient come to terms with a secret.
Zoe feels dissatisfied with life as she turns 40 while Cal steals Ethan's proposal idea but is exposed with some help from Lily.